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- Title
Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506).
- Authors
Daeschler, Simeon C.; Feinberg, Konstantin; Harhaus, Leila; Kneser, Ulrich; Gordon, Tessa; Borschel, Gregory H.
- Abstract
Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuroregenerative properties, has emerged in experimental studies as a promising candidate to accelerate nerve fiber regeneration. This review investigates the therapeutic potential of tacrolimus by exploring the postulated mechanisms of action in relation to biological barriers to nerve injury recovery. By mapping both the preclinical and clinical evidence, the benefits and drawbacks of systemic tacrolimus administration and novel delivery systems for localized tacrolimus delivery after nerve injury are elucidated. Through synthesizing the current evidence, identifying practical barriers for clinical translation, and discussing potential strategies to overcome the translational gap, this review provides insights into the translational perspectives of tacrolimus as an adjunct therapy for nerve regeneration.
- Subjects
PERIPHERAL nerve injuries; TACROLIMUS; IMMUNOSUPPRESSIVE agents; NERVOUS system injuries; NERVE fibers; NERVOUS system regeneration
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 16, p12771
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241612771