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- Title
Electrical and Structural Insights into Right Ventricular Outflow Tract Arrhythmogenesis.
- Authors
Lu, Yen-Yu; Chen, Yao-Chang; Lin, Yung-Kuo; Chen, Shih-Ann; Chen, Yi-Jen
- Abstract
The right ventricular outflow tract (RVOT) is the major origin of ventricular arrhythmias, including premature ventricular contractions, idiopathic ventricular arrhythmias, Brugada syndrome, torsade de pointes, long QT syndrome, and arrhythmogenic right ventricular cardiomyopathy. The RVOT has distinct developmental origins and cellular characteristics and a complex myocardial architecture with high shear wall stress, which may lead to its high vulnerability to arrhythmogenesis. RVOT myocytes are vulnerable to intracellular sodium and calcium overload due to calcium handling protein modulation, enhanced CaMKII activity, ryanodine receptor phosphorylation, and a higher cAMP level activated by predisposing factors or pathological conditions. A reduction in Cx43 and Scn5a expression may lead to electrical uncoupling in RVOT. The purpose of this review is to update the current understanding of the cellular and molecular mechanisms of RVOT arrhythmogenesis.
- Subjects
ARRHYTHMIA; ARRHYTHMOGENIC right ventricular dysplasia; VENTRICULAR arrhythmia; BRUGADA syndrome; LONG QT syndrome; RYANODINE receptors
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 14, p11795
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241411795