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- Title
Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury.
- Authors
Wang, Zufeng; Luo, Chengliang; Zhou, Edward W.; Sandhu, Aaron F.; Yuan, Xiaojing; Williams, George E.; Cheng, Jialu; Sinha, Bharati; Akbar, Mohammed; Bhattacharya, Pallab; Zhou, Shuanhu; Song, Byoung-Joon; Wang, Xin
- Abstract
The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities.
- Subjects
ALCOHOLISM; POST-traumatic stress disorder; BRAIN injuries; GENETIC regulation; PATHOLOGICAL physiology
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 10, p8805
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24108805