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- Title
The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat.
- Authors
Hammad, Fayez T.; Lubbad, Loay; Al-Salam, Suhail; Yasin, Javed; Meeran, Mohamed Fizur Nagoor; Ojha, Shreesh; Hammad, Waheed F.
- Abstract
Both ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversible UO has not been studied previously. To study this effect, spontaneously hypertensive (G-HT, n = 10) and normotensive Wistar (G-NT, n = 10) rats underwent 48-h reversible left unilateral UO (UUO), and the effect of UUO was studied 96 h following UUO reversal. The glomerular filtration rate, renal blood flow, and renal tubular functions such as the fractional excretion of sodium in the post-obstructed left kidney (POK) in both groups were significantly altered compared with the non-obstructed right kidney (NOK). However, the alterations in the G-HT were significantly more exaggerated when compared with the G-NT. Similar findings were observed with the histological features, gene expression of kidney injury markers, pro-inflammatory, pro-fibrotic and pro-apoptotic cytokines, and pro-collagen, as well as tissue levels of apoptotic markers. We conclude that hypertension has significantly exaggerated the alterations in renal functions and other parameters of renal injury associated with UUO.
- Subjects
RATS; URETERIC obstruction; KIDNEYS; KIDNEY diseases; KIDNEY pelvis; GLOMERULAR filtration rate; CHRONIC kidney failure; HYPERTENSION
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 8, p7365
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24087365