We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson.
- Authors
Tassone, Annalisa; Meringolo, Maria; Ponterio, Giulia; Bonsi, Paola; Schirinzi, Tommaso; Martella, Giuseppina
- Abstract
Strong evidence suggests a correlation between degeneration and mitochondrial deficiency. Typical cases of degeneration can be observed in physiological phenomena (i.e., ageing) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have the dyshomeostasis of mitochondrial bioenergy as a common denominator. Neurodegenerative diseases show bioenergetic imbalances in their pathogenesis or progression. Huntington's chorea and Parkinson's disease are both neurodegenerative diseases, but while Huntington's disease is genetic and progressive with early manifestation and severe penetrance, Parkinson's disease is a pathology with multifactorial aspects. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early-onset diseases linked to gene mutations, while others could be idiopathic, appear in young adults, or be post-injury senescence conditions. Although Huntington's is defined as a hyperkinetic disorder, Parkinson's is a hypokinetic disorder. However, they both share a lot of similarities, such as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc. In this review, we will describe the start and development of both diseases in relation to mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.
- Subjects
HUNTINGTON disease; PARKINSON'S disease; NEURODEGENERATION; PATHOLOGY; MITOCHONDRIA
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 8, p7221
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24087221