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- Title
Structures and Anti-Inflammatory Evaluation of Phenylpropanoid Derivatives from the Aerial Parts of Dioscorea polystachya.
- Authors
Cai, Baixiang; Cai, Xinyin; Xu, Tao; Wang, Jutao; Yu, Yang
- Abstract
Seven undescribed phenylpropanoid constituents, including three new bibenzyl derivatives (1–3) along with four new benzofuran stilbene derivatives (4–7), were isolated from the aerial parts of Dioscorea polystachya. The structures of these compounds were elucidated using a combination of spectroscopic analyses, including UV, IR, HRESIMS, 1D, and 2D NMR. Further, all the compounds were evaluated on the anti-inflammatory activity for their inhibition of nitric oxide (NO) production by RAW 264.7 macrophages cells, and some of them (1–3 and 6) displayed inhibitory activity with IC50 values in the range of 9.3–32.3 μM. Moreover, compound 3 decreased the expression of iNOS in Western blot analysis, suggesting compound 3 is mediated via the suppression of an LPS-induced NF-κB inflammasome pathway.
- Subjects
YAMS; PHENYLPROPANOIDS; STILBENE derivatives; NITRIC oxide; ANTI-inflammatory agents; WESTERN immunoblotting
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 18, pN.PAG
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms231810954