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- Title
Is Melanoma Progression Affected by Thyroid Diseases?
- Authors
Ulisse, Salvatore; Baldini, Enke; Pironi, Daniele; Gagliardi, Federica; Tripodi, Domenico; Lauro, Augusto; Carbotta, Sabino; Tarroni, Danilo; D'Armiento, Matteo; Morrone, Aldo; Forte, Flavio; Frattaroli, Flaminia; Persechino, Severino; Odorisio, Teresa; D'Andrea, Vito; Lori, Eleonora; Sorrenti, Salvatore
- Abstract
Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic–pituitary–thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients.
- Subjects
THYROTROPIN releasing factor; THYROID diseases; MELANOMA; THYROID hormones
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 17, p10036
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms231710036