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- Title
DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review.
- Authors
Visconti, Virginia Veronica; Cariati, Ida; Fittipaldi, Simona; Iundusi, Riccardo; Gasbarra, Elena; Tarantino, Umberto; Botta, Annalisa
- Abstract
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.
- Subjects
DNA methylation; BONE metabolism; OSTEOPOROSIS; OSTEOARTHRITIS; DNA; DUAL-energy X-ray absorptiometry; GENE expression
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 8, p4244
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22084244