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- Title
The Functions and Therapeutic Potential of Heat Shock Proteins in Inflammatory Bowel Disease—An Update.
- Authors
Hoter, Abdullah; Naim, Hassan Y.
- Abstract
Inflammatory bowel disease (IBD) is a multifactorial human intestinal disease that arises from numerous, yet incompletely defined, factors. Two main forms, Crohn's disease (CD) and ulcerative colitis (UC), lead to a chronic pathological form. Heat shock proteins (HSPs) are stress-responsive molecules involved in various pathophysiological processes. Several lines of evidence link the expression of HSPs to the development and prognosis of IBD. HSP90, HSP70 and HSP60 have been reported to contribute to IBD in different aspects. Moreover, induction and/or targeted inhibition of specific HSPs have been suggested to ameliorate the disease consequences. In the present review, we shed the light on the role of HSPs in IBD and their targeting to prevent further disease progression.
- Subjects
HEAT shock proteins; INFLAMMATORY bowel diseases; CROHN'S disease; POTENTIAL functions; ULCERATIVE colitis; INTESTINAL diseases
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 21, p5331
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20215331