We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
7-Methylguanosine Modifications in Transfer RNA (tRNA).
- Authors
Tomikawa, Chie
- Abstract
More than 90 different modified nucleosides have been identified in tRNA. Among the tRNA modifications, the 7-methylguanosine (m7G) modification is found widely in eubacteria, eukaryotes, and a few archaea. In most cases, the m7G modification occurs at position 46 in the variable region and is a product of tRNA (m7G46) methyltransferase. The m7G46 modification forms a tertiary base pair with C13-G22, and stabilizes the tRNA structure. A reaction mechanism for eubacterial tRNA m7G methyltransferase has been proposed based on the results of biochemical, bioinformatic, and structural studies. However, an experimentally determined mechanism of methyl-transfer remains to be ascertained. The physiological functions of m7G46 in tRNA have started to be determined over the past decade. For example, tRNA m7G46 or tRNA (m7G46) methyltransferase controls the amount of other tRNA modifications in thermophilic bacteria, contributes to the pathogenic infectivity, and is also associated with several diseases. In this review, information of tRNA m7G modifications and tRNA m7G methyltransferases is summarized and the differences in reaction mechanism between tRNA m7G methyltransferase and rRNA or mRNA m7G methylation enzyme are discussed.
- Subjects
METHYLGUANOSINE; GUANOSINE derivatives; TRANSFER RNA structure; TRANSFER RNA synthetases; LIGASES
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 12, p4080
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19124080