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- Title
A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent.
- Authors
Eun Ju Oh; Jong Il Park; Ji Eun Lee; Cheol Hwan Myung; Su Yeon Kim; Sung Eun Chang; Jae Sung Hwang
- Abstract
BW723C86, a serotonin receptor 2B agonist, has been investigated as a potential therapeutic for various conditions such as anxiety, hyperphagia and hypertension. However, the functional role of BW723C86 against melanogenesis remains unclear. In this study, we investigate the effect of serotonin receptor 2B (5-HTR2B) agonist on melanogenesis and elucidate the mechanism involved. BW723C86 reduced melanin synthesis and intracellular tyrosinase activity in melan-A cells and normal human melanocytes. The expression of melanogenesis-related proteins (tyrosinase, TRP-1 and TRP-2) and microphthalmia-associated transcription factor (MITF) in melan-A cells decreased after BW723C86 treatment. The promoter activity of MITF was also reduced by BW723C86 treatment. The reduced level of MITF was associated with inhibition of protein kinase A (PKA) and cAMP response element-binding protein (CREB) activation by BW723C86 treatment. These results suggest that the serotonin agonist BW723C86 could be a potential therapeutic agent for skin hyperpigmentation disorders.
- Subjects
SEROTONIN receptors; HYPERPIGMENTATION; MELANOGENESIS; PHENOL oxidase; PROTEIN expression; DIAGNOSIS
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 4, p546
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17040546