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- Title
Prediction of Bioluminescent Proteins Using Auto Covariance Transformation of Evolutional Profiles.
- Authors
Xiaowei Zhao; Jiakui Li; Yanxin Huang; Zhiqiang Ma; Minghao Yin
- Abstract
Bioluminescent proteins are important for various cellular processes, such as gene expression analysis, drug discovery, bioluminescent imaging, toxicity determination, and DNA sequencing studies. Hence, the correct identification of bioluminescent proteins is of great importance both for helping genome annotation and providing a supplementary role to experimental research to obtain insight into bioluminescent proteins' functions. However, few computational methods are available for identifying bioluminescent proteins. Therefore, in this paper we develop a new method to predict bioluminescent proteins using a model based on position specific scoring matrix and auto covariance. Tested by 10-fold cross-validation and independent test, the accuracy of the proposed model reaches 85.17% for the training dataset and 90.71% for the testing dataset respectively. These results indicate that our predictor is a useful tool to predict bioluminescent proteins. This is the first study in which evolutionary information and local sequence environment information have been successfully integrated for predicting bioluminescent proteins. A web server (BLPre) that implements the proposed predictor is freely available.
- Subjects
PROTEIN genetics; BIOLUMINESCENCE; MEMBRANE proteins; AMINO acid sequence; NUCLEOTIDE sequence; ANALYSIS of covariance; TOXICITY testing; GENOMES
- Publication
International Journal of Molecular Sciences, 2012, Vol 13, Issue 3, p3650
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms13033650