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- Title
Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years.
- Authors
Yea Ji Kim; Mi Yeon Lee; Yang, A. Ram; In Suk Sol; Ji Hee Kwak; Hye Lim Jung; Jae Won Shim; Deok Soo Kim; Jung Yeon Shim
- Abstract
Purpose: Climate and lifestyle changes increase an individual's susceptibility to various allergens and also the incidence of allergic diseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. Materials and Methods: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiary hospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E (IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and tree pollen mixtures, as well as cat and dog dander through ImmunoCAP test. Results: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for tree pollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p for trend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens (=2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization to D. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). Conclusion: Children's sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased during the 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.
- Subjects
SOUTH Korea; ALLERGENS; ALLERGIES; IMMUNOGLOBULIN E; ALLERGIC rhinitis; ALTERNARIA; ATOPY
- Publication
Yonsei Medical Journal, 2020, Vol 61, Issue 9, p797
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2020.61.9.797