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- Title
Dyspnea as a Prognostic Factor in Patients with Non-Small Cell Lung Cancer.
- Authors
Wooho Ban; Jong Min Lee; Jick Hwan Ha; Chang Dong Yeo; Hyeon Hui Kang; Chin Kook Rhee; Hwa Sik Moon; Sang Haak Lee
- Abstract
Purpose: To investigate associations between dyspnea and clinical outcomes in patients with non-small cell lung cancer (NSCLC). Materials and Methods: From 2001 to 2014, we retrospectively reviewed the prospective lung cancer database of St. Paul's Hospital at the Catholic University of Korea. We enrolled patients with NSCLC and evaluated symptoms of dyspnea using modified Medical Research Council (mMRC) scores. Also, we estimated pulmonary functions and analyzed survival data. Results: In total, 457 NSCLC patients were enrolled, and 259 (56.7%) had dyspnea. Among those with dyspnea and whose mMRC scores were available (109 patients had no mMRC score), 85 (56.6%) patients had an mMRC score <2, while 65 (43.3%) had an mMRC score =2. Significant decreased pulmonary functions were observed in patients with dyspnea. In multivariate analysis, aging, poor performance status, advanced stage, low forced expiratory volume in 1 second (%), and an mMRC score =2 were found to be significant prognostic factors for patient survival. Conclusion: Dyspnea could be a significant prognostic factor in patients with NSCLC.
- Subjects
NON-small-cell lung carcinoma; ST. Paul's Hospital (Vancouver, B.C.); MEDICAL Research Council (Organization); MULTIVARIATE analysis; DYSPNEA; PROGNOSIS; PATIENTS
- Publication
Yonsei Medical Journal, 2016, Vol 57, Issue 5, p1063
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2016.57.5.1063