We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetics of florfenicol following intravenous and intramuscular administration in dogs.
- Authors
BIRDANE, Y. O.; BIRDANE, F. M.
- Abstract
Florfenicol is a synthetic broad-spectrum antibiotic used to treat infectious diseases in veterinary medicine. Limited information is available on the pharmacokinetics and bioavailability of lorfenicol in dogs. his study was conducted in six healthy dogs to determine the bioavailability and pharmacokinetics of lorfenicol following a single intravenous (i.v.) and intramuscular (i.m.) dose of 30 mg/kg body weight (b.w.). Blood samples were taken over the course of 24 h post-treatment and the recovered plasma was extracted and analysed using high-performance liquid chromatography (HPLC). Pharmacokinetic analysis was performed using a two-compartment open model. After i.v. administration of lorfenicol, elimination half-life (t1/2b), volume of distribution at steady state (Vdss), total body clearance (ClT) and area under curve (AUC0-24) were 3.09 ± 0.13 h, 1.19 ± 0.15 l/kg, 0.37 ± 0.04 l/h/kg, and 59.44 ± 5.27 µg/h/ml, respectively. he peak plasma concentration (Cmax), time to maximum concentration (tmax) and bioavailability (F) were 3.05 ± 0.43 µg/ml, 1.50 ± 0.35 h, and 44.70 ± 6.75%, respectively, following i.m. administration. In this study the time that plasma concentration exceed the concentration of 1 µg/ml was approximately 8 h. herefore, lorfenicol should be given twice daily at a dosage of 30 mg/kg b.w. to maintain therapeutic concentration. he pharmacokinetic proile of lorfenicol in dogs reveals that it may be therapeutically useful against susceptible microorganisms involved in most common infections in dogs.
- Subjects
PHARMACOKINETICS; THIAMPHENICOL; INTRAMUSCULAR injections; DOG diseases; COMMUNICABLE diseases in animals; VETERINARY medicine; BIOAVAILABILITY; VETERINARY therapeutics
- Publication
Veterinární Medicína, 2015, Vol 60, Issue 6, p323
- ISSN
0375-8427
- Publication type
Article
- DOI
10.17221/8247-VETMED