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- Title
The relationships among biological membranes and signaling mediators. II. How do the receptors find and identify their targets?
- Authors
Kurchii, B. A.
- Abstract
Although many components of the signaling pathways are known, nevertheless, how mitogen activated protein kinase signaling pathways relay, integrate and transmit signals from a diverse range of intra cellular and extracellular stimuli to nuclear DNA remains an open question for now. How do RNA polymerase or DNA polymerase's find and identify their targets avoiding fruitless searching through mega bases of non-target DNA? In this paper I review how this sequence searching may be done. I described an alternative perception mechanism of intra cellular and extracellular stimuli and transduction them to nuclear DNA using as a messenger (a receptor) the short DNA strands i.e. primers. I believe that so called receptors (transcription factors) are synthesized simultaneously with membranes and stored in the rafts of membranes upon their damage by chemical or physical factors. Liberated during membrane destruction these receptors (signaling molecules), called by us as gene keys, conjoin with the template DNA strands at the promoter (gene locks) through non-covalent bonds with AT base pairs. Thus, the gene key dictates when, where and what specific genes are transcribed.
- Subjects
BIOLOGICAL membranes; DNA; DNA polymerases; HORMONE receptors; SINGLE cell proteins; PHYSIOLOGY
- Publication
Ukrainica Bioorganica Acta, 2010, Vol 8, Issue 2, p31
- ISSN
1814-9758
- Publication type
Article