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- Title
The influence of the HLA-DRB1 and HLA-DQB1 allele heterogeneity on disease risk and severity in Iranian patients with multiple sclerosis.
- Authors
Kollaee, A.; Ghaffarpor, M.; Ghlichnia, H. A.; Ghaffari, S. H.; Zamani, M.
- Abstract
Multiple sclerosis (MS) is a common autoimmune disorder of the central nervous system. Recent studies have shown that the HLA-DRB1 and DQB1 alleles are associated with MS susceptibility and severity. However, this is controversial in different population studies. In the present study, the roles of HLA-DRB1 and DQB1 alleles and the amino acids were investigated on disease risk and severity in 120 Iranian patients with MS and 120 controls. Our findings indicate that the DRB1*1501 allele (OR = 3.203 P = 0.001), the DRB1*1501-DQB1*0602 haplotype (OR = 7.792 P = 0.003) and the DRB1*1501/0701- genotype (OR = 3.320 P = 0.006) and amino acid Leu26 (OR = 1.645 P = 0.005) and Phe9 (OR = 1.893 P = 0.009) on the DQβ1 chain are significantly associated with MS susceptibility. DRB1*1001 was the only allele that had a protective effect against MS ( P = 0.0004). We also found that the DQB1*0303 allele was significantly associated with disease severity (mean Multiple Sclerosis Severity Score difference = 1.979, P = 0.002). However, protective effect of the DRB1*1001 against MS and also association of DQB1*0303 allele with MS severity need to be confirmed by larger sample size.
- Subjects
HLA histocompatibility antigens; GENE frequency; MULTIPLE sclerosis risk factors; IRANIANS; AUTOIMMUNE diseases; CENTRAL nervous system diseases; SAMPLE size (Statistics); DISEASES
- Publication
International Journal of Immunogenetics, 2012, Vol 39, Issue 5, p414
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2012.01104.x