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- Title
Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO.
- Authors
Nomura, S.; Shouzu, A.; Omoto, S.; Matsuzaki, T.; Yamaoka, M.; Abe, M.; Hosokawa, M.; Nishikawa, M.; Iwasaka, T.; Fukuhara, S.
- Abstract
We examined the genetic status of human leucocyte antigens (HLA), human platelet alloantigens (HPA) and neutrophil-specific antigens (NA) in patients with type 2 diabetes mellitus and diabetic arteriosclerosis obliterans (ASO). To our knowledge, the present study is the first report showing the relationship among three genetic factors in type 2 diabetes mellitus and ASO patients. HLA typing was performed by the polymerase chain reaction (PCR)–restriction fragment length polymorphism method. HPA-typing and NA-typing were by a PCR-sequence-specific primer method. The incidence of HLA-DRB1*1501 was found to be significant in type 2 diabetes and non-diabetic, particularly ASO-positive patients, compared to control subjects. There were no differences in NA1/NA2 between the control and diabetic or non-diabetic ASO groups. However, the frequency of NA2/NA2 in ASO-positive diabetes and non-diabetic ASO patients was significantly higher than controls. The a/b genotype of HPA-5a/5b was significantly lower in type 2 diabetes and non-diabetic ASO-positive patients than in controls. These findings suggest that genetic studies of HLA, NA and HPA could be useful to understand the pathogenesis of type 2 diabetes and ASO.
- Subjects
LEUCOCYTE disorders; LEUCOCYTES; ANTIGENS; TYPE 2 diabetes; DIABETES; ARTERIOSCLEROSIS obliterans; GENETIC disorders
- Publication
International Journal of Immunogenetics, 2006, Vol 33, Issue 2, p117
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2006.00581.x