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- Title
Cheater suppression and stochastic clearance through quorum sensing.
- Authors
Moffett, Alexander S.; Thomas, Peter J.; Hinczewski, Michael; Eckford, Andrew W.
- Abstract
The evolutionary consequences of quorum sensing in regulating bacterial cooperation are not fully understood. In this study, we reveal unexpected effects of regulating public good production through quorum sensing on bacterial population dynamics, showing that quorum sensing can be a collectively harmful alternative to unregulated production. We analyze a birth-death model of bacterial population dynamics accounting for public good production and the presence of non-producing cheaters. Our model demonstrates that when demographic noise is a factor, the consequences of controlling public good production according to quorum sensing depend on the cost of public good production and the growth rate of populations in the absence of public goods. When public good production is inexpensive, quorum sensing is a destructive alternative to unconditional production, in terms of the mean population extinction time. When costs are higher, quorum sensing becomes a constructive strategy for the producing strain, both stabilizing cooperation and decreasing the risk of population extinction. Author summary: Quorum sensing is a process through which bacteria can regulate gene expression according to their population density. The reasons for why bacteria use quorum sensing to regulate production of "public goods", biochemical products that benefit nearby bacteria, are not entirely clear. We use mathematical modeling to explore how quorum sensing compares to other strategies for controlling production of public goods, namely unconditional production independent on population density, in small populations of bacteria where the random nature of growth is significant. Our model captures both how likely "cheater" strains, which do not produce public goods but benefit from them, are to take over a population and how long on average the population will last before going extinct. We find that depending on how expensive public good production is and how critical public goods are for growth, quorum sensing can decrease or increase the mean time to extinction compared with unconditional production, while always reducing the likelihood of cheaters taking over. Our results could have important implications for the growth of bacterial infections, for example Pseudomonas aeruginosa infections of the lungs of cystic fibrosis patients.
- Subjects
QUORUM sensing; PSEUDOMONAS aeruginosa infections; PUBLIC goods; PULMONARY fibrosis; BACTERIAL population; COMMON good
- Publication
PLoS Computational Biology, 2022, Vol 18, Issue 7, p1
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.1010292