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- Title
The Association Between Allostatic Load and Frailty Trajectories Among Adults Aged 50+ Years: Mediating Role of Physical Activity.
- Authors
Shi, Kanglin; He, Lingxiao; Zhang, Zeyun; Lin, Jianlin; Chen, Xiaodong; Du, Xinyuan; Shi, Kewei; Yang, Jinzhu; Shi, Zaixing; Fang, Ya
- Abstract
Objectives: To identify frailty trajectories and examine its association with allostatic load (AL) and mediating effect of physical activity (PA). Methods: This study included 8,082 adults from the English Longitudinal Study of Aging over Waves 4–9. AL was calculated by 14 biological indicators, and a 53-item frailty index was used to evaluate frailty. Frailty trajectories were classified by group-based trajectory modeling, and the mediated effect of PA was tested by causal mediation analysis. Results: Four frailty trajectories were identified: "Robustness" (n = 4,437, 54.9%), "Incident prefrailty" (n = 2,061, 25.5%), "Prefrailty to frailty" (n = 1,136, 14.1%), and "Frailty to severe frailty" (n = 448, 5.5%). High baseline AL was associated with increased odds of "Incident prefrailty," "Prefrailty to frailty," and "Frailty to severe frailty" trajectories. PA demonstrated significant mediated effects in aforementioned associations. Conclusions: AL is significantly associated with the onset and progression of frailty, and such associations are partially mediated by PA.
- Subjects
BIOMARKERS; FRAIL elderly; FUNCTIONAL status; PHYSICAL activity; PHYSIOLOGICAL adaptation; RISK assessment; SEVERITY of illness index; FACTOR analysis; QUESTIONNAIRES; ATTRIBUTION (Social psychology); RESEARCH funding; OLD age
- Publication
Journal of Aging & Physical Activity, 2024, Vol 32, Issue 1, p8
- ISSN
1063-8652
- Publication type
Article
- DOI
10.1123/japa.2022-0441