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- Title
Generation of transgenic corn-derived Actinobacillus pleuropneumoniae ApxIIA fused with the cholera toxin B subunit as a vaccine candidate.
- Authors
Min-Kyoung Shin; Myung Hwan Jung; Won-Jung Lee; Pil Son Choi; Yong-Suk Jang; Han Sang Yoo
- Abstract
Corn, one of the most important forage crops worldwide, has proven to be a useful expression vehicle due to the availability of established transformation procedures for this well-studied plant. The exotoxin Apx, a major virulence factor, is recognized as a common antigen of Actinobacillus (A.) pleuropneumoniae, the causative agent of porcine pleuropneumonia. In this study, a cholera toxin B (CTB)-ApxIIA#5 fusion protein and full-size ApxIIA expressed in corn seed, as a subunit vaccine candidate, were observed to induce Apx-specific immune responses in mice. These results suggest that transgenic corn-derived ApxIIA and CTB-ApxIIA#5 proteins are potential vaccine candidates against A. pleuropneumoniae infection.
- Subjects
ACTINOBACILLUS; CHOLERA toxin; GENE expression; MICROBIAL virulence; VIRAL vaccines; IMMUNE response; LABORATORY mice; VIRAL proteins
- Publication
Journal of Veterinary Science, 2011, Vol 12, Issue 4, p401
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2011.12.4.401