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- Title
Differential brain angiotensin-II type I receptor expression in hypertensive rats.
- Authors
Braga, Valdir A.
- Abstract
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II- dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and the rostral ventrolateral medulla (RVLM). Male Wistar rats were implanted with 14-day osmotic minipump filled with Ang-II (150 ng/kg/min) or saline. AT1 receptor mRNA levels were detected in the SFO and RVLM by reverse transcription-polymerase chain reaction (RT-PCR). Ang-II caused hypertension (134 ± 10 mmHg vs. 98 ± 9 mmHg, n = 9, p < 0.05). RT-PCR revealed that Ang-II infusion induced increased AT1 receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT1 receptors.
- Subjects
ANGIOTENSIN II; HYPERTENSION; CELL receptors; MESSENGER RNA; REVERSE transcriptase polymerase chain reaction; LABORATORY rats; BRAIN physiology; LOSARTAN; BLOOD pressure
- Publication
Journal of Veterinary Science, 2011, Vol 12, Issue 3, p291
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2011.12.3.291