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- Title
Experimental reproduction of proliferative enteropathy and the role of IFN-γ in protective immunity against Lawsonia intracellularis in mice.
- Authors
Yun-Young Go; Jeong-Keun Lee; Jeong-Yong Ye; Joong-Bok Lee; Seung-Yong Park; Chang-Seon Song; Soo-Ki Kim; In-Soo Choi
- Abstract
Proliferative enteropathy was reproduced in IFN-γ receptor knockout (IFN-γ R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-γ were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-γ Produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.
- Subjects
INTESTINAL diseases; LABORATORY mice; CECUM; LAWSONIA; LYTHRACEAE; LARGE intestine
- Publication
Journal of Veterinary Science, 2005, Vol 6, Issue 4, p357
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2005.6.4.357