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- Title
Protective effect of <italic>Uncaria tomentosa</italic> extract against oxidative stress and genotoxicity induced by glyphosate-Roundup® using zebrafish (<italic>Danio rerio</italic>) as a model.
- Authors
Santo, Glaucia Dal; Grotto, Alan; Boligon, Aline A.; Da Costa, Bárbara; Rambo, Cassiano L.; Fantini, Emily A.; Sauer, Elisa; Lazzarotto, Luan M. V.; Bertoncello, Kanandra T.; Júnior, Osmar Tomazelli; Garcia, Solange C.; Siebel, Anna M.; Rosemberg, Denis B.; Magro, Jacir Dal; Conterato, Greicy M. M.; Zanatta, Leila
- Abstract
Oxidative stress and DNA damage are involved in the glyphosate-based herbicide toxicity. <italic>Uncaria tomentosa</italic> (UT; Rubiaceae) is a plant species from South America containing bioactive compounds with known beneficial properties. The objective of this work was to evaluate the antioxidant and antigenotoxic potential of UT extract in a model of acute exposure to glyphosate-Roundup® (GR) in zebrafish (<italic>Danio rerio</italic>). We showed that UT (1.0 mg/mL) prevented the decrease of brain total thiols, the increase of lipid peroxidation in both brain and liver, and the decrease of liver GPx activity caused after 96 h of GR (5.0 mg/L) exposure. In addition, UT partially protected against the increase of micronucleus frequency induced by GR exposure in fish brain. Overall, our results indicate that UT protects against damage induced by a glyphosate-based herbicide by providing antioxidant and antigenotoxic effects, which may be related to the phenolic compounds identified in the extract.
- Subjects
OXIDATIVE stress; DNA damage; GLYPHOSATE; HERBICIDES; UNCARIA tomentosa
- Publication
Environmental Science & Pollution Research, 2018, Vol 25, Issue 12, p11703
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-018-1350-6