We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The antibiotic resistome: the nexus of chemical and genetic diversity.
- Authors
Wright, Gerard D.
- Abstract
Over the millennia, microorganisms have evolved evasion strategies to overcome a myriad of chemical and environmental challenges, including antimicrobial drugs. Even before the first clinical use of antibiotics more than 60 years ago, resistant organisms had been isolated. Moreover, the potential problem of the widespread distribution of antibiotic resistant bacteria was recognized by scientists and healthcare specialists from the initial use of these drugs. Why is resistance inevitable and where does it come from? Understanding the molecular diversity that underlies resistance will inform our use of these drugs and guide efforts to develop new efficacious antibiotics.
- Subjects
DRUG resistance in microorganisms; ANTIBIOTICS; MOLECULAR biology; DRUG efficacy; ENVIRONMENTAL degradation; SCIENTISTS
- Publication
Nature Reviews Microbiology, 2007, Vol 5, Issue 3, p175
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1614