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- Title
Precise hit: adeno-associated virus in gene targeting.
- Authors
Vasileva, Ana; Jessberger, Rolf
- Abstract
Vectors based on the adeno-associated virus (AAV) have attracted much attention as potent gene-delivery vehicles, mainly because of the persistence of this non-pathogenic virus in the host cell and its sustainable therapeutic gene expression. However, virus infection can be accompanied by potentially mutagenic random vector integration into the genome. A novel approach to AAV-mediated gene therapy based on gene targeting through homologous recombination allows efficient, high-fidelity, non-mutagenic gene repair in a host cell.
- Subjects
ADENOVIRUSES; DNA viruses; GENE therapy; VIRUS diseases; MUTAGENESIS; THERAPEUTICS; GENOMES
- Publication
Nature Reviews Microbiology, 2005, Vol 3, Issue 11, p837
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1266