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- Title
Author's reply: Plasma corticosteroid‐binding globulin levels in cirrhosis.
- Authors
Wentworth, Brian J.; Schliep, Matthew; Siragy, Helmy M.; Henry, Zachary H.
- Abstract
We thank Dr. Lee and colleagues for their interest in our systematic review and meta-analysis on relative adrenal insufficiency (RAI) in cirrhosis[1] and wish to comment on their letter.[2] We agree that total cortisol (TC) levels are an imperfect assessment of patient adrenal function in cirrhosis given their dependence on the availability of liver-derived binding proteins. High serum levels of free cortisol indicate severity of cirrhosis in hemodynamically stable patients. The authors' sub-fractionation of CBG is interesting and their finding of an elevated high-affinity proportion[2] may indicate a potential compensatory response to cirrhosis-related alterations in cortisol homeostasis.
- Subjects
CIRRHOSIS of the liver; GLOBULINS; ADRENAL insufficiency
- Publication
Liver International, 2023, Vol 43, Issue 3, p742
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.15525