The article focuses on the initiation process of messenger ribonucleic acid (mRNA) degradation. It states that the addition of uridine contributes to the mRNA degradation pathway in the growth development in yeast and metazoans. It reveals that the removal of poly(A) is an initial step for mRNA degradation yeast and metazoans development. It also provides information on uridylation and deadenylation process as part of mRNA degradation.