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- Title
Copper-Catalyzed Difunctionalization of Terminal Alkynes with Diazo Esters and Amines to Construct β-Enamino Esters.
- Authors
Gao, Bao; Huang, Hanmin
- Abstract
An operationally simple and efficient copper-catalyzed three-component tandem reaction of terminal alkynes, diazo compounds and amines to yield β-enamino esters is described. This straightforward protocol takes place rapidly with a wide range of substrates and gives the desired β-enamino esters in good to excellent yields. Preliminary mechanistic studies suggested that the reaction probably proceeds through Cu-catalyzed formal C-H insertion to produce an alkynoate intermediate, which was then trapped by amines to give the β-enamino esters.
- Subjects
COPPER; METALS; ALKYNES; HYDROCARBONS; ESTERS
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 24, p4075
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201600883