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- Title
Synthesis and Duplex Stabilization of Oligonucleotides Consisting of Isonucleosides.
- Authors
Yang, Zhenjun; Zhang, Huyi; Min, Jimei; Ma, Lingtai; Zhang, Lihe
- Abstract
Novel oligonucleotide analogues built from isonucleosides were synthesized by the phosphoramidite approach on an automated DNA synthesizer. The phosphoramidite building blocks were synthesized by phosphitylation of the corresponding protected isonucleosides. The oligonucleotide analogues C - G containing the isonucleoside 1 - 3 were studied with respect to their hybridization properties and enzymatic stability. The oligomers bearing an isonucleoside at the end of the strands all proved stable towards snake-venom phosphodiesterase, but only the oligomers D - G exhibit acceptable duplex stability when hybridized with complementary d(A14).
- Publication
Helvetica Chimica Acta, 1999, Vol 82, Issue 11, p2037
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I