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- Title
Changes in anti-heat shock protein 27 antibody and C-reactive protein levels following cardiac surgery and their association with cardiac function in patients with cardiovascular disease.
- Authors
Rahsepar, Amir; Mirzaee, Asadollah; Moodi, Fatemeh; Moohebati, Mohsen; Tavallaie, Shima; Khorashadizadeh, Fatemeh; Eshraghi, Ali; Alavi, Maryam-Sadat; Zarrabi, Laya; Sajjadian, Mostafa; Amini, Maral; Khojasteh, Roshanak; Paydar, Roghayeh; Mousavi, Somayeh; Ghayour-Mobarhan, Majid; Ferns, Gordon
- Abstract
The relationship between serum anti-heat shock protein (Hsp)27 antibody and high sensitive C-reactive protein (hs-CRP) levels and indices of cardiac function were investigated in patients undergoing coronary artery bypass grafting (CABG) or heart valve replacement. The changes in anti-Hsp27 antibody titers and hs-CRP levels were compared among patients undergoing off-pump and on-pump CABG or valvular heart replacement. Fifty-three patients underwent off-pump, on-pump CABG, and heart valvular replacement in each group. Serum anti-Hsp27 titers and hs-CRP values were measured 24 h before and after the operation and at discharge. Echocardiography was performed before surgery and before discharge. The results were compared with values from 83 healthy controls. hs-CRP levels increased and anti-Hsp27 antibody decreased following surgery ( P < 0.001 and P < 0.05, respectively), although these changes were independent of operative procedure ( P = 0.361 and P = 0.120, respectively). Anti-Hsp27 antibody levels were higher at the time of discharge ( P = 0.016). Only in coronary patients were anti-Hsp27 antibody levels negatively associated with E/E′ ( r = −0.268, P = 0.022), a marker of pulmonary capillary wedge pressure. In conclusions, anti-Hsp27 antibody levels are associated with indices of cardiac function in coronary patients. Cardiopulmonary bypass had no significant effect on the induction of changes in anti-Hsp27 levels. Moreover, anti-Hsp27 antibody levels fell in all groups postoperatively; this may be due to the formation of immune complexes of antigen-antibody, and antibody levels were higher at the time of discharge.
- Subjects
CARDIOVASCULAR diseases; HEAT shock proteins; IMMUNOGLOBULINS; C-reactive protein; CARDIAC surgery; ECHOCARDIOGRAPHY; CARDIOPULMONARY bypass; ANTIGEN-antibody reactions
- Publication
Cell Stress & Chaperones, 2013, Vol 18, Issue 1, p65
- ISSN
1355-8145
- Publication type
Article
- DOI
10.1007/s12192-012-0358-y