We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Microbial resistance related to antibiotic-loaded bone cement: a historical review.
- Authors
Walker, Lucy; Baker, Paul; Holleyman, Richard; Deehan, David; Walker, Lucy C
- Abstract
<bold>Purpose: </bold>The use of antibiotic-loaded bone cement (ALBC) has a range of indications for use in orthopaedics. It has the advantage of delivering high loads of antibiotics to a targeted site, thereby avoiding the side effects associated with systemic administration. However, there is concern that the use of ALBC may precipitate the development of antibiotic-resistant bacteria.<bold>Methods: </bold>This review focuses on (1) the published research using both animal and human models examining the association between ALBC and the induction of microbial resistance (2) the mechanisms by which antimicrobial resistance develop (3) the research pertaining to specific classes of antibiotics commonly used in orthopaedic practice (4) the recent developments in calcium sulphate beads, nanoparticles and chitosan, as alternative antimicrobial treatments for periprosthetic joint infections.<bold>Conclusion: </bold>The literature for and against a link between ALBC and the development of microbiological resistance is reviewed and presented. It is concluded that further research is needed to develop a defined set of indications for the use of ALBC in the management of periprosthetic joint infection. In addition, further research into alternative antimicrobial therapies in this area should be encouraged.
- Subjects
BONE cements; DRUG resistance in bacteria; ANTIBIOTICS; TARGETED drug delivery; JOINT infections; CALCIUM sulfate; NANOPARTICLES; CHITOSAN; ANIMALS; DRUG resistance in microorganisms; JOINTS (Anatomy); ORTHOPEDICS
- Publication
Knee Surgery, Sports Traumatology, Arthroscopy, 2017, Vol 25, Issue 12, p3808
- ISSN
0942-2056
- Publication type
journal article
- DOI
10.1007/s00167-016-4309-5