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- Title
Survival, surgical management and perioperative mortality of colorectal cancer in the 21-year experience of a specialised registry.
- Authors
Ponz de Leon, Maurizio; Pezzi, Annalisa; Benatti, Piero; Manenti, Antonio; Rossi, Giuseppina; di Gregorio, Carmela; Roncucci, Luca
- Abstract
A general improvement of colorectal cancer prognosis has been observed. Reasons of this more favourable trend are diffusion of screening, advancements in molecular biology, new developments in chemotherapy and surgical techniques. Through the data of a colorectal cancer registry, we purposed to evaluate changes in surgical procedures for colorectal neoplasms and to analyse trends of perioperative mortality. Patients with colorectal cancer were registered from 1984 to 2004. The main surgical procedures were recorded and classified. Perioperative mortality was defined as death of patients within 1 month since the operation. Regression analysis showed an increase over time of right and left hemicolectomy. Both colectomy and endoscopic polypectomy showed significant rise over time. In contrast, abdominoperineal operations dropped during the study period. A similar decrease was observed for palliative surgery. Perioperative mortality declined from 7–11% to 3–6% of all operations; main factors associated with perioperative mortality were presence of comorbidities, increasing age and advanced stage. The better prognosis of patients with colorectal cancer was associated with changes of surgical techniques, with a tendency to prefer large operations over limited resections. Perioperative mortality showed a gradual decrease and is at present in the order of 3% to 6% of all operations.
- Subjects
CANCER-related mortality; OPERATIVE surgery; COLON cancer prognosis; DRUG therapy; HEMICOLECTOMY
- Publication
International Journal of Colorectal Disease, 2009, Vol 24, Issue 7, p777
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-009-0687-1