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- Title
Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes.
- Authors
Koponen, Anne; Peltonen, Juha; Päivinen, Marja; Aho, Jyrki; Hägglund, Harriet; Uusitalo, Arja; Lindholm, Harri; Tikkanen, Heikki
- Abstract
Blood O carrying capacity affects aerobic capacity ( VO). Patients with type 1 diabetes have a risk for anaemia along with renal impairment, and they often have low VO. We investigated whether total haemoglobin mass (tHb-mass) and blood volume (BV) differ in men with type 1 diabetes (T1D, n = 12) presently without complications and in healthy men (CON, n = 23) (age-, anthropometry-, physical activity-matched), to seek an explanation for low VO. We determined tHb-mass, BV, haemoglobin concentration ([Hb]), and VO in T1D and CON. With similar (mean ± SD) [Hb] (144 vs. 145 g l), T1D had lower tHb-mass (10.1 ± 1.4 vs. 11.0 ± 1.1 g kg, P < 0.05), BV (76.8 ± 9.5 vs. 83.5 ± 8.3 ml kg, P < 0.05) and VO (35.4 ± 4.8 vs. 44.9 ± 7.5 ml kg min, P < 0.001) than CON. VO correlated with tHb-mass and BV both in T1D ( r = 0.71, P < 0.01 and 0.67, P < 0.05, respectively) and CON ( r = 0.54, P < 0.01 and 0.66, P < 0.001, respectively), but not with [Hb]. Linear regression slopes were shallower in T1D than CON both between VO and tHb-mass (2.4 and 3.6 ml kg min vs. g kg, respectively) and VO and BV (0.3 and 0.6 ml kg min vs. g kg, respectively), indicating that T1D were unable to reach similar VO than CON at a given tHb-mass and BV. In conclusion, low tHb-mass and BV partly explained low VO in T1D and may provide early and more sensitive markers of blood O carrying capacity than [Hb] alone.
- Subjects
HEMOGLOBINS; BLOOD volume; AEROBIC capacity; PEOPLE with diabetes; PHYSICAL activity; DIABETES
- Publication
European Journal of Applied Physiology, 2013, Vol 113, Issue 5, p1181
- ISSN
1439-6319
- Publication type
Article
- DOI
10.1007/s00421-012-2532-4