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- Title
Haptoglobin genotype and endothelial function in diabetes mellitus: a pilot study.
- Authors
Dayan, Lior; Levy, Andrew P.; Blum, Shany; Miller-Lotan, Rachel; Melman, Uzi; Alshiek, Jonia; Jacob, Giris
- Abstract
Endothelial function (EnF) is impaired in patients with diabetes mellitus (DM) due in large part to an increase in oxidative stress. Haptoglobin (Hp) is a potent antioxidant protein which is encoded by two different alleles (1 and 2) with the Hp 1 protein being a superior antioxidant to the Hp 2 protein. We hypothesized that DM individuals with the Hp 2-2 genotype would have greater endothelial dysfunction as compared to DM individuals with the Hp 1-1 genotype. We studied EnF in 16 Hp 2-2, 14 Hp 1-1 DM individuals and 14 healthy subjects. DM patients' groups were matched in terms of age, cardiovascular risk factors and metabolic characteristics. EnF was assessed using post-ischemic reactive hyperemia and strain gauge plethysmography and expressed either as the maximal flow after the ischemic period or as the area under the flow-time curve (AUC). We showed that EnF indices, AUC and maximal flow, were also higher in the healthy and Hp 1-1 groups compared with Hp 2-2 genotype group (615 +/- 60 and 600 +/- 40 vs. 450 +/- 50 ml dl(-1), 29 +/- 2.6 and 25 +/- 3 vs. 14 +/- 1.8 ml min(-1) dl(-1), P < 0.003 and P < 0.05, for AUC and maximal flow, one-way ANOVA, respectively). We concluded that Hp 2-2 diabetic patients had a worse EnF than controls and Hp 1-1 diabetic subjects.
- Subjects
HAPTOGLOBINS; ENDOTHELIAL seeding; DIABETES; OXIDATIVE stress; ANTIOXIDANTS; BLOOD flow measurement; BLOOD proteins; VASODILATION; COMPARATIVE studies; ENDOTHELIUM; GLOBULINS; HEMODYNAMICS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; PILOT projects; EVALUATION research; IN vitro studies
- Publication
European Journal of Applied Physiology, 2009, Vol 106, Issue 4, p639
- ISSN
1439-6319
- Publication type
journal article
- DOI
10.1007/s00421-009-1048-z