We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Noninvasive Measurement of the Maximum Relaxation Rate of Inspiratory Muscles in Patients with Neuromuscular Disorders.
- Authors
Garcïa-Rïo, F.; Mediano, O.; Pino, J. M.; Lores, V.; Fernández, I.; Alvarez-Sala, J. L.; Villamor, J.
- Abstract
Background: Slowing of inspiratory muscle relaxation has been used as an index for inspiratory muscle fatigue. However, maximum relaxation rate measured from oesophageal pressure traces after maximum sniff (Poes MRR) has limited clinical usefulness because it requires an oesophageal balloon catheter system. Objectives: It was the aim of this study to establish whether, in neuromuscular patients, maximum relaxation rate assessed from sniff nasal pressure (Pnasal MRR) reflects oesophageal MRR and the tension-time index of the diaphragm (TTdi). Methods: Twenty patients with neuromuscular disease and 10 healthy subjects were studied. Poes and transdiaphragmatic pressure were measured while Pnasal was recorded with a balloon advanced through the nose into the nasopharynx. Maximum Poes, transdiaphragmatic pressure and Pnasal were simultaneously measured while the patients performed maximal sniffs. The MRR (% pressure fall/10 ms) for each sniff, the TTdi and the tension-time index of respiratory muscles were determined. Results: Neuromuscular patients showed higher TTdi, lower Poes MRR and lower Pnasal MRR than the control group. In patients with neuromuscular disease, the correlation coefficient of Pnasal MRR and Poes MRR was 0.985 (p < 0.001). Regression analysis showed that Poes MRR = –1.101 + 1.113·Pnasal MRR (r2 = 0.929, standard error of the estimate = 0.208). Indeed, Pnasal MRR was negatively correlated with TTdi (r = –0.914, p < 0.001) and the tension-time index of respiratory muscles (r = –0.732, p < 0.001). In the neuromuscular group, the mean difference between Pnasal MRR and Poes MRR was 0.286 ± 0.217%/10 ms. Conclusions: Pnasal MRR obtained from a maximal sniff accurately reflects Poes MRR and TTdi in patients with neuromuscular disorders. Copyright © 2006 S. Karger AG, Basel
- Subjects
RELAXATION for health; NEUROMUSCULAR diseases; MUSCLE diseases; NEUROLOGICAL disorders; MEDICAL care
- Publication
Respiration, 2006, Vol 73, Issue 4, p474
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000091804