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- Title
Enhancement of the Antibiotic Activity against a Multiresistant Escherichia coli by Mentha arvensis L. and Chlorpromazine.
- Authors
Coutinho, Henrique D. M.; Costa, José G. M.; Lima, Edeltrudes O.; Falcão-Silva, Vivyanne S.; Siqueira-Júnior, José P.
- Abstract
Background: This is the first report testing the antibiotic resistance-modifying activity of Mentha arvensis. Methods: In this study an ethanol extract of M. arvensis L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against strains of Escherichia coli. Results: The growth of two E. coli strains tested was not inhibited by the extract. The minimum inhibitory concentration and minimal bactericide concentration values were ≥1 mg/ml for both strains of E. coli used. A potentiating effect of this extract on gentamicin was demonstrated. Similarly, there was a potentiating effect of chlorpromazine on kanamycin, amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. Conclusions: It is therefore suggested that extracts from M. arvensis could be used as a source of plant-derived natural products with resistance-modifying activity, such as in the case of gentamicin, constituting a new weapon against bacterial resistance to antibiotics, as with chlorpromazine. Copyright © 2008 S. Karger AG, Basel
- Subjects
ESCHERICHIA coli; ANTIBIOTICS; CHLORPROMAZINE; MICROBIAL metabolites; GENTAMICIN
- Publication
Chemotherapy (0009-3157), 2008, Vol 54, Issue 4, p328
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000151267