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- Title
Wiedemann–Steiner Syndrome with a Pathogenic Variant in KMT2A from Taiwan.
- Authors
Chung-Lin Lee; Chih-Kuang Chuang; Huei-Ching Chiu; Ru-Yi Tu; Yun-Ting Lo; Ya-Hui Chang; Hsiang-Yu Lin; Shuan-Pei Lin
- Abstract
Wiedemann–Steiner syndrome (WSS) is a rare genetic disorder. Patients with WSS have characteristics of growth retardation, facial dysmorphism, hypertrichosis cubiti (HC), and neurodevelopmental delays. WSS is in an autosomal dominant inherited pattern caused by a mutation of the KMT2A gene (NM_001197104.2). In this article, we discuss a 5-year-old boy who has mild intellectual disability (ID), hypotonia, HC, hypertrichosis on the back, dysmorphic facies, psychomotor retardation, and growth delay. Trio-based whole-exome sequencing (trio-WES) was carried out on this patient and his parents, confirming the variants with Sanger sequencing. Trio-WES showed a de novo mutation of the KMT2A gene (NM_001197104.2: c.4696G>A, p.Gly1566Arg). On the basis of the clinical features and the results of the WES, WSS was diagnosed. Therefore, medical professionals should consider a diagnosis of WSS if patients have growth retardation and development delay as well as hirsutism, particularly HC.
- Subjects
TAIWAN; PROTEUS syndrome; GENETIC disorders in children; HYPERTRICHOSIS; FACIAL abnormalities; EXOMES
- Publication
Children, 2021, Vol 8, Issue 11, p1
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children8110952