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- Title
Structural biology: A moving story of receptors.
- Authors
Schwartz, Thue W.; Hubbell, Wayne L.
- Abstract
The article discusses the significance of G-protein coupled receptors on animal cell membranes. It is noted that G-protein is also known as 7TM receptors because of their seven transmembrane helices which are involved in sensing light and a multitude of chemical signals. Meanwhile, rhodopsin has been seen as the archetypal 7TM receptor because of the detailed biophysical and structural data were available for it. In addition, the observed conformation of activated opsin on the intracellular side of the cell membrane probably represents the activated state for 7TM receptors in general.
- Subjects
G proteins; CELL membranes; RHODOPSIN; VISUAL pigments; CELL receptors; CHEMICAL senses; BIOPHYSICS; ANIMALS; ANATOMY; BIOLOGICAL research
- Publication
Nature, 2008, Vol 455, Issue 7212, p473
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/455473a