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- Title
Wound repair and regeneration.
- Authors
Gurtner, Geoffrey C.; Werner, Sabine; Barrandon, Yann; Longaker, Michael T.
- Abstract
The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.
- Subjects
WOUND healing; SCARS; GRANULATION tissue; REGENERATION (Biology); CELL growth; CELL proliferation; ANTIBIOTICS; HEALING; BIOLOGY
- Publication
Nature, 2008, Vol 453, Issue 7193, p314
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature07039