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- Title
Interventions for relieving pain associated with panretinal photocoagulation: a prospective randomized trial.
- Authors
Wu, W.-C.; Hsu, K.-H.; Chen, T.-L.; Hwang, Y.-S.; Lin, K.-K.; Li, L.-M.; Shih, C.-P.; Lai, C.-C.
- Abstract
PurposeTo evaluate the efficacy of pain relief by oral diazepam, acetaminophen, mefenamic acid, intramuscular ketorolac tromethamine, and peribulbar anaesthesia in panretinal photocoagulation (PRP).MethodsA total of 220 patients with proliferative diabetic retinopathy requiring PRP treatment were enrolled in this study. Before laser treatment, the patients were allocated randomly to one of eight groups: group 1: diazepam (n=22), group 2: acetaminophen (n=21), group 3: mefenamic acid (n=21), group 4: diazepam and acetaminophen (n=22), group 5: diazepam and mefenamic acid (n=22), group 6: peribulbar anaesthesia with lidocaine (n=23), group 7: intramuscular injection of ketorolac tromethamine (n=22), group 8: placebo (n=67). Pain after the laser treatment was assessed by a verbal descriptive scale. Blood pressure and heart rate were measured before and after laser treatment.ResultsPatients receiving peribulbar anaesthesia had a significantly lower pain score than the control group (P<0.0001). Additionally, the peribulbar anaesthesia-treated group had the significantly least PRP-associated rise in either systolic (P=0.043) or diastolic blood pressure rates (P=0.030). There were no significant differences in pain score using other anesthetic agents when compared with the control group. There were no significant changes in heart rate after PRP treatment.ConclusionPeribulbar anaesthesia is effective in reducing pain and blood pressure increase after PRP treatment. Oral diazepam, mefenamic acid, and acetaminophen (either alone or in combination with each other) are not effective in preventing PRP treatment-associated pain. Intramuscular injection of ketorolac tromethamine is also not effective in reducing PRP-associated pain.Eye (2006) 20, 712–719. doi:10.1038/sj.eye.6701989; published online 8 July 2005
- Subjects
DIAZEPAM; ACETAMINOPHEN; MEFENAMIC acid; LIGHT coagulation; EYE diseases; OPHTHALMOLOGY
- Publication
Eye, 2006, Vol 20, Issue 6, p712
- ISSN
0950-222X
- Publication type
Article
- DOI
10.1038/sj.eye.6701989