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- Title
Isolation of malignant and functional Ly 1<sup>+</sup> T-cell clones from B-cell lymphomas.
- Authors
Reinisch, Carol L.; Sing, Amy P.; Waldron, James A.; Kemp, John D.
- Abstract
Recent work has shown that established B-cell tumours, previously thought to proliferate independently of immune regulation, may activate, and be regulated by, helper or suppressor T-cell subpopulations1-7. We now report a unique model of a murine sarcoma virus (MSV) induced B-cell lymphoma which is closely associated with a population of pre-malignant or malignant helper T cells. Proliferation of these T cells is not observed in vivo but is readily detected on in vitro cultivation. These results raise questions about immunological control and differentiation of malignant lymphomas in vivo.
- Publication
Nature, 1982, Vol 298, Issue 5870, p176
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/298176a0