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- Title
The Effects of Synbiotic Supplementation on the Serum Endotoxin Level, Inflammatory Status, and Clinical Outcomes of Critically Ill Adult Patients: A Randomized Controlled Trial.
- Authors
Seifi, Najmeh; Sedaghat, Alireza; Nematy, Mohsen; Rezaiyan, Majid Khadem; Shirazinezhad, Reza; Ranjbar, Golnaz; Safarian, Mohammad
- Abstract
Background: Gut microbiota dysbiosis, endotoxemia, and systemic inflammation are major contributing factors to disease pathophysiology in critically ill patients. The present study aimed to assess the effects of synbiotic supplementation on the serum endotoxin and inflammation of critically ill adult patients. Materials: This double-blind, randomized, controlled trial was conducted at the intensive care unit (ICU) of Imam Reza Hospital in Mashhad, Iran. In the intervention group, 20 patients received synbiotic capsules (containing a combination of Lactobacillus, Bifidobacterium, Streptococcus, and fructooligosaccharides) twice per day for a maximum of 14 days. In the control group, 18 patients received placebo capsules. The serum levels of endotoxin and C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR) were measured before and after the intervention. In addition, clinical outcomes and the scores of Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) were recorded. Results: Basic characteristics were similar in the intervention and control groups. The NLR and serum endotoxin levels significantly reduced in the synbiotic group (7.83 [4.58-12.57]-6.01 [4.25-9.38]; P= 0.04 and 11.98 [10.64-12.65]- 10.58 [9.41-12.34]; P=0.03, respectively). However, no significant changes were observed in the mentioned parameters in the placebo group. The clinical outcomes were also similar in the study groups, such as the length of hospital/ICU stay and hospital/28-day mortality rate. Conclusion: Although synbiotic supplementation (500 mg twice daily for 14 days) could reduce serum endotoxin and inflammatory markers, it had no effects on the clinical outcomes of the patients.
- Subjects
CRITICALLY ill patient care; SYNBIOTICS; DIETARY supplements; ENDOTOXIN analysis; INFLAMMATION
- Publication
Journal of Nutrition, Fasting & Health, 2022, Vol 10, p305
- ISSN
2821-2746
- Publication type
Article