We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amaranthus hybridus (Amaranthaceae) prevents the detrimental effects of cyclophosphamide on ovarian function in Wistar rats: An experimental study.
- Authors
Watcho, Pierre; Nsamou Ngueyong, Prechmy Carole; Defo Deeh, Patrick Brice; Bonsou Fozin, Georges Romeo; Ngadjui, Esther; Wankeu-Nya, Modeste; Kamtchouing, Pierre
- Abstract
Background: Cyclophosphamide (CP) is an anticancer agent, but its chronic administration induces ovarian toxicity. Objective: We evaluated the effects of aqueous extract (AE) and methanol extract (ME) of Amaranthus hybridus (A. hybridus) on CP-induced ovarian toxicity in rats. Materials and Methods: 40 female Wistar rats (10 wk, 170-200 gr) were distributed into 8 groups (n = 5/each) as follows: 1) healthy control; 2) CP+distilled water (10 ml/kg/d); 3) CP+3%-tween 80 (10 mL/kg/d); 4) CP+clomiphene citrate (2 mg/kg/d); 5, 6) CP+AE of A. hybridus (55 and 110 mg/kg/d); and 7, 8) CP+ME of A. hybridus (55 and 110 mg/kg/d). After 28 days of treatment, estrus cyclicity, ovarian and uterine weights as well as estradiol levels and ovarian histology were determined. Results: CP induced ovarian toxicity after 28 days of exposure. More specifically, CP disturbed the estrus cycle, decreased ovary and uterus weights (p = 0.04), and the 17-β estradiol level (p = 0.04), and induced severe ovarian damages. Remarkably, A. hybridus significantly increased (p = 0.03) the ovarian weight (AE and ME at all doses) and uterus weight (ME at 110 mg/kg/d), compared with the CP-treated rats. Moreover, the 17-β estradiol level was significantly elevated (p = 0.02) in rats given clomiphene citrate and A. hybridus (AE 110 mg/kg/d; ME 55 mg/kg/d). Finally, the ovaries of rats given plant extracts had many corpus luteum and normal follicles, and no cystic follicles. Conclusion: A. hybridus prevented the detrimental effects of CP on ovarian function, which could support its traditional use as a fertility enhancer.
- Subjects
OVARIES; LABORATORY rats; CORPUS luteum; AMARANTHACEAE; AMARANTHS
- Publication
International Journal of Reproductive Biomedicine, 2022, Vol 20, Issue 8, p651
- ISSN
2476-4108
- Publication type
Article
- DOI
10.18502/ijrm.v20i8.11754