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- Title
Effects of Supplement (γ-aminobutyric acid (GABA)) Administration, Aromatherapy, and Mindfulness Meditation as Complementary and Alternative Medicine on the Salivary Oxytocin Concentration in Healthy Individuals.
- Authors
Chiyomi Okamoto; Yuichiro Kurone; Chiaki Takagi; Naoto Hirata; Saori Nakagawa; Eiichi Tachikawa; Susumu Yamato; Shin Ohta; Sadahiko Shimoeda
- Abstract
Introduction: Anticancer agents induce a variety of adverse drug reactions. These adverse drug reactions cause very strong physical and psychological stress and may make continuation of treatment difficult. In addition, a stress-related increase in sympathetic tone has been reported to affect exacerbation/metastasis of breast cancer. Therefore, alleviation of stress is an important factor for improving the outcome of cancer treatment. We conducted supplement (y-aminobutyric acid (GABA)) administration, aromatherapy, and mindfulness meditation (MM) as complementary and alternative medicine (CAM) and evaluated their stress-mitigating effects using the salivaiy oxytocin (OT) concentration as an index. Methods: Test 1 and Test 2 were carried out in health volunteers. Test 1 was evaluation of short-term effects of CAM. Each CAM therapy was applied once in 26 subjects (12 males and 14 females, mean age: 22.8士 1.4 years), and the OT concentration was determined in saliva collected before and after the application. Test 2 was evaluation of long-term effects of CAM. Each CAM therapy was applied daily for 6 weeks in the same 17 subjects (7 males and 10 females, mean age: 24.3±2.0 years), and the OT concentration was determined in saliva collected at awakening once every week. Results: In Test 1,no CAM caused a significant increase in the salivary OT concentration. In Test 2, however,the salivary OT concentration increased significantly in the 4 males who practiced MM. Conclusions: MM increased the salivary OT concentration in some healthy males, but the other 2 therapies had no sufficient effect on the salivary OT concentration. However, as the subjects in this study were healthy individuals, the effects of CAM under usual stress may not be measured accurately. Therefore, it is necessary for the future to evaluate the clinical usefulness of CAM, particularly MM, in high-stress groups such as cancer patients. In conclusion, it is important that the results obtained in this study may be effective against the very high stress of cancer patients.
- Subjects
SALIVA; OXYTOCIN; DRUG side effects; MINDFULNESS; GABA; AROMATHERAPY; PSILOCYBIN
- Publication
Pharmacometrics / Ōyō Yakuri (0300-8533), 2020, Vol 99, Issue 5/6, p109
- ISSN
0300-8533
- Publication type
Article