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- Title
Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
- Authors
Blackledge, Neil P.; Rose, Nathan R.; Klose, Robert J.
- Abstract
Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that Polycomb repressive complexes (PRCs) recognize and are recruited to their genomic target sites through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.
- Subjects
POLYCOMB group proteins; GENOMICS; VERTEBRATES; PROTEINS; RNA
- Publication
Nature Reviews Molecular Cell Biology, 2015, Vol 16, Issue 11, p643
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm4067