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- Title
Diversity and selectivity in mRNA translation on the endoplasmic reticulum.
- Authors
Reid, David W.; Nicchitta, Christopher V.
- Abstract
Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum (ER). Subsequent investigations revealed a specialized function for each population, with secretory and integral membrane protein-encoding mRNAs translated on ER-bound ribosomes, and cytosolic protein synthesis was widely attributed to free ribosomes. Recent findings have challenged this view, and transcriptome-scale studies of mRNA distribution and translation have now demonstrated that ER-bound ribosomes also function in the translation of a large fraction of mRNAs that encode cytosolic proteins. These studies suggest a far more expansive role for the ER in transcriptome expression, where membrane and secretory protein synthesis represents one element of a multifaceted and dynamic contribution to post-transcriptional gene expression.
- Subjects
MESSENGER RNA; GENETIC translation; ENDOPLASMIC reticulum; EUKARYOTIC cell genetics; ELECTRON microscopy; RIBOSOMES
- Publication
Nature Reviews Molecular Cell Biology, 2015, Vol 16, Issue 4, p221
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3958