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- Title
Surveillance pathways rescuing eukaryotic ribosomes lost in translation.
- Authors
Graille, Marc; Séraphin, Bertrand
- Abstract
Living cells require the continuous production of proteins by the ribosomes. Any problem enforcing these protein factories to stall during mRNA translation may then have deleterious cellular effects. To minimize these defects, eukaryotic cells have evolved dedicated surveillance pathways: non-stop decay (NSD), no-go decay (NGD) and non-functional 18S-rRNA decay (18S-NRD). Recent studies support a general molecular framework for these surveillance pathways, the mechanisms of which are intimately related to translation termination.
- Subjects
EUKARYOTIC cells; RIBOSOMES; NUCLEOPROTEINS; ORGANELLES; MESSENGER RNA; CYTOPLASM
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 11, p727
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3457