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- Title
Apoptosis: A lipid trigger of MOMP.
- Authors
David, Rachel
- Abstract
The article discusses research being done on mitochondrial outer membrane permeabilization (MOMP), apoptosis' mitochondrial pathway. It references the study "Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis," by J. E. Chipuk and colleagues in the 2012 issue of "Cell." Results show that ceramides' metabolization by enzymes like sphingosine kinase 2 (SPHK2) allows S1P and hex, that promote BAX and BAK activation and cytochrome release and MOMP.
- Subjects
SPHINGOLIPIDS; MITOCHONDRIA; LIPIDS; SPHINGOSINE kinase; CERAMIDES
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 4, p208
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3316