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- Title
The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon
- Authors
Matsuyama, Noriko; Mishiro, Shunji; Sugimoto, Masanobu; Furuichi, Yasuhiro; Hashimoto, Michie; Hijikata, Minako; Ohta, Yasuhiko
- Abstract
We studied a possible correlation between the dinucleotide microsatellite polymorphism of the interferon α/β receptor-1 gene (IFNAR1) and responsiveness of hepatitis C patients to interferon therapy. The length of GT-repeat (n of (GT)n) in the IFNAR1 promoter was determined in 157 patients, of whom 50 were responders and 107 were nonresponders to interferon. The genotypes 5/5 (i.e. homozygotes of (GT)5) and 5/14 (i.e. heterozygotes of (GT)5 and (GT)14) were more frequently found in responders than in nonresponders: 80 versus 58%, P=0.008. Thus, determining (GT)n of the IFNAR1 promoter may help predict treatment outcome in patients treated with interferon α and/or β. In addition, we sought for genetic polymorphism in the promoter region of the interferon α/β receptor-2 gene (IFNAR2), and found single nucleotide polymorphisms (SNPs) at −134 and −75. But these SNPs did not show a clinical significance, as compared with the GT-repeat in IFNAR1, in the context of interferon responsiveness.
- Subjects
GENETIC polymorphisms; MICROSATELLITE repeats; INTERFERONS; HEPATITIS C
- Publication
Hepatology Research, 2003, Vol 25, Issue 3, p221
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1016/S1386-6346(02)00269-3